If you’re looking for a crowd-pleasing, comforting meal, this Italian Sausage Penne Casserole is your go-to. Loaded with savory Italian sausage, tender penne pasta, tangy tomatoes, and gooey mozzarella cheese, it’s like lasagna without the fuss.
16 oz penne pasta
2 lb hot Italian sausage (or sweet/mild)
24 oz shredded mozzarella cheese
1 medium onion, diced
5 cloves garlic, minced
28 oz can diced tomatoes
1½ tsp dried basil
1½ tsp dried oregano
Salt and pepper, to taste
Non-stick cooking spray
Prep casserole dish & oven:
Preheat oven to 350°F (175°C) and spray a 3-quart casserole dish with non-stick spray.
Cook sausage:
Remove sausage from casing and crumble into a large skillet. Cook over medium heat until browned. Drain excess grease, reserving 2 tablespoons, and set sausage aside.
Sauté vegetables:
Add reserved grease to skillet. Sauté onion and garlic until onions are translucent.
Add tomatoes & seasonings:
Pour in diced tomatoes. Add basil, oregano, salt, and pepper. Cook over medium heat for 5 minutes.
Combine sausage & simmer:
Return sausage to skillet. Bring mixture to a boil, then cover and simmer on low for 20–30 minutes, stirring occasionally.
Cook pasta:
Prepare penne according to package directions for al dente. Drain, rinse, and return to pot.
Mix pasta & sauce:
Stir sausage mixture into pasta. Add half of the mozzarella and stir until melted.
Assemble casserole:
Place half of the pasta mixture into the prepared casserole dish. Sprinkle with cheese, then add the remaining pasta and top with remaining mozzarella.
Bake:
Cover with foil and bake 30 minutes until heated through. Remove foil and bake a few more minutes for golden, bubbly cheese.
Serve:
Slice and serve hot with salad and garlic bread.
Sausage choice: Hot Italian sausage adds a kick; sweet sausage works for a milder flavor.
Cheese options: Mix mozzarella with provolone or parmesan for extra richness.
Make ahead: Assemble casserole and refrigerate for up to 24 hours before baking.
Freezing: Fully cooked and cooled casserole can be frozen in portions for up to 2 months. Reheat covered in the oven.